Preheat your oven to 350°F (175°C) and lightly grease a loaf pan.
In a large bowl, combine ground beef, breadcrumbs, milk, onion, egg, garlic, ketchup, Worcestershire sauce, oregano, salt, and pepper. Mix until well combined.
Transfer the mixture into the prepared loaf pan, shaping it into a loaf.
Bake in the preheated oven for 50-60 minutes or until the internal temperature reaches 160°F (70°C).
Let the meatloaf rest for 10 minutes before slicing and serving.